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BSCI 207 HW #9: Neurons DUE SAT Nov 12, 2016 @ noon 1. A) In a neuron, the sodium /
potassium pump sets up the ion
concentration gradient. During an
action potential, the ion pump
works continuously. There are
three different types of ion channels
(leaky K channels, voltage gated
Na channels, voltage gated K
channels) through which ions
move. Fill in the following table for
the five key phases of the action
potential. List the approximate
membrane potential and the status
(open, closed, inhibited) of the
three key ion channels during each phase. Phase Membrane potential K leaky Gated Na channel 1. Resting
3. Rising phase 75 mV Open Closed Na flow
None Gated K channel K flow and direction Closed None 4. Falling phase
1. Resting 2. You can run the neuron simulation from PhET: http://phet.colorado.edu/en/simulation/neuron
to watch the movement of ions during an action potential. In the simulation, pick ?show concentrations?. a. What is the K+ concentration inside the neuron and how does it vary during an action potential? b. How is the Na+ concentrations and how does it vary? c. How does this simplify calculations of the membrane potential using the Goldman
3. A red blood cell has different concentration of ions inside and outside the cell. a. Given the concentrations shown below, and the ion channel permeabilities (PK = 1.0; PNa = 0.54, PCl = 0.21) use the Goldman equation to solve for the membrane potential. What then is the relative potential inside the cell compared to outside (i.e. is it positive or negative)? b. A red blood cell is not a neuron and so certainly doesn?t need a membrane potential to generate action potentials. Why might this cell have concentration gradients of ions and hence a membrane potential across its membrane? Think back to some of Dr Eric?s lectures about membrane transport. Gated Channel How do ions move? Depolarize / hyperpolarize Neurotransmitter release Sodium channels open
Sodium channels close and potassium channels open
Potassium channels close
4. During this action potential, the cell will depolarize and hyperpolarize. When this occurs close to the synapse, it will affect the release of neurotransmitter. Fill in what happens:
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